Sonic Hedgehog Induces Roof Plate

Sonic hedgehog is a protein that in humans is encoded by the shh gene.

Sonic hedgehog induces roof plate.

Sonic hedgehog induces semaphorin responsiveness in pre crossing commissural axons. In vertebrates it is involved in organogenesis including the growth of digits on limbs and the organization of the brain. Shh induces the expression of sclerotomal markers such as pax1and sox9 fan and tessier lavigne 1994. In addition motor neuron differentiation can be in duced in neural plate explants by a diffusible factor derived.

Midline floor plate and roof plate cells respectively. Floor plate cells in vitro can also be induced in neural plate explants grown in contact with cells transfected shh roelink et al 1994. Embryos mutant for a deletion of syu d. Ericson et al 1995.

We show that the zebrafish sonic you syu gene a member of a group of five genes required for somite patterning is encoding shh. Sonic hedgehog shh is a secreted protein that is involved in the organization and patterning of several tissues in vertebrates. Roof plate cells of the neural tube liem et al 1995 which specify a subset of interneurons in the dorsal neural tube lee. After sonic hedgehog shh signalling from the notochord induces its formation the floor plate of the incipient neural tube also secretes shh.

It is the best studied ligand of the hedgehog signaling pathway others being desert hedgehog dhh and indian hedgehog ihh. Shh expression in the notochord and floor plate also sonic hedgehog induces floor plate gene expression 1427 figure s. Figure 1 sonic hedgehog induces semaphorin responsiveness in pre crossing commissural axons. A a schematic diagram of rat e13 embryo microdissections of pre crossing explants from the dorsal.

Sonic hedgehog shh is a secreted protein that is involved in the organization and patterning of several tissues in vertebrates. It plays a key role in the development of animals from insects to mammals. Tanabe et al 1995. B gene expression in cps from mcre.

A a schematic diagram of rat e13. We show that the zebrafish sonic you syu gene a member of a group of five genes required for somite patterning is encoding shh. Sonic hedgehog shh a cholesterol modified. The basal plate.

After closure the neural tube forms a basal or floor plate and a roof or alar plate in response to the combined effects of shh and factors including bmp4 secreted by the roof plate. Activation of mouse shh and hnf3 3 in wexp2 cshh transgenic embryos a j transverse sections through an 11 5 dpc transgenic embryo hybridized with hnf3 f a f and i mouse shh b d g and j and chick shh c e and h.